The big upset at last night’s 64th annual Golden Globe awards was Ugly Betty’s America Ferrerra winning in the best actress in a comedy category against four other women who had all been nominated before. Ferrerra beat out Marcia Cross and Felicity Huffman of Desperate Housewives, Julia Louis-Dreyfus from The New Adventures Of Old Christine and Mary-Louise Parker of Weeds.

Ugly Betty also took home the Globe for best Comedy series. Other nominees in the category were Desperate Housewives, Entourage, The Office and Weeds.

The best actor in a drama was my husband’s favorite, Hugh Laurie of House. He beat out Micheal C. Hall in Dexter, Patrick Dempsey of Grey’s Anatomy, Bill Paxton in Big Love and Kiefer Sutherland of 24.

Grey’s Anatomy received the Globe for best drama, against Heroes, Big Love, 24 and Lost.

Here’s the full list of winners:

Series, Drama: “Grey’s Anatomy,” ABC

Actress, Drama: Kyra Sedgwick, “The Closer”

Actor, Drama: Hugh Laurie, “House”

Series, Musical or Comedy: “Ugly Betty,” ABC

Actress, Musical or Comedy: America Ferrera, “Ugly Betty”

Actor, Musical or Comedy: Alec Baldwin, “30 Rock”

Miniseries or movie: “Elizabeth I,” HBO

Actress, Miniseries or Movie: Helen Mirren, “Elizabeth I”

Actor, Miniseries or Movie: Bill Nighy, “Gideon’s Daughter”

Supporting Actress, Series, Miniseries or Movie: Emily Blunt, “Gideon’s Daughter”

Supporting Actor, Series, Miniseries or Movie: Jeremy Irons, “Elizabeth I”

Cecil B. DeMille Award: Warren Beatty

You can view the nominations to see who lost in each category.

Here are some pictures of America Ferrarra, found at Gossip Rocks. More pictures from the Globes will be up momentarily.